Development of a fluorescent probe for the study of the sponge-derived simplexide immunological properties
Articolo
Data di Pubblicazione:
2012
Citazione:
Development of a fluorescent probe for the study of the sponge-derived simplexide immunological properties / R. Di Brisco, F. Ronchetti, A. Mangoni, V. Costantino, F. Compostella. - In: CARBOHYDRATE RESEARCH. - ISSN 0008-6215. - 348(2012), pp. 27-32. [10.1016/j.carres.2011.11.017]
Abstract:
Simplexide is a glycolipid of marine origin, endowed with immunological properties, composed of a long chain secondary alcohol glycosylated by an α-d-glucosyl-(1→4)-β-d-galactosyl disaccharide residue. Herein we describe the preparation of a fluorescent derivative of simplexide, labeled at position 6 of the distal glucose with a dansyl group, as a probe for future studies on the mechanism by which simplexide affects the immune system. Fluorescent simplexide was prepared from a 6″-amino functionalized compound, which in turn was obtained through a highly efficient glycosylation between the preformed activated disaccharide and the long chain secondary alcohol 18-pentatriacontanol.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Fluorescent probes; Glycolipids; Marine compounds
Elenco autori:
R. Di Brisco, F. Ronchetti, A. Mangoni, V. Costantino, F. Compostella
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