Activation of the orphan nuclear receptor RORα induces growth arrest in androgen-independent DU 145 prostate cancer cells
Articolo
Data di Pubblicazione:
2001
Citazione:
Activation of the orphan nuclear receptor RORα induces growth arrest in androgen-independent DU 145 prostate cancer cells / R.M. Moretti, M. Montagnani Marelli, M. Motta, D. Polizzi, S. Monestiroli, G. Pratesi, P. Limonta. - In: THE PROSTATE. - ISSN 0270-4137. - 46:4(2001 Mar 01), pp. 327-335. [10.1002/1097-0045(20010301)46:4<327::AID-PROS1040>3.0.CO;2-6]
Abstract:
RORalpha is a transcription factor which belongs to the family of orphan nuclear receptors. The regulatory functions of this receptor are still poorly understood. However, response elements for RORalpha are present on the promoter of cell cycle-related genes suggesting that it might be involved in the control of cell proliferation. In this study, we investigated the expression and the possible function of RORalpha in a human androgen-independent prostate cancer cell line (DU 145). The thiazolidinedione-derivative CGP 52608 has been utilized as the specific ligand and activator of RORalpha.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cell cycle-related genes; Cell proliferation; Orphan nuclear receptors; Prostate cancer
Elenco autori:
R.M. Moretti, M. Montagnani Marelli, M. Motta, D. Polizzi, S. Monestiroli, G. Pratesi, P. Limonta
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