ALLERGIA ALLE PROTEINE DEL LATTE VACCINO E IMPIEGO DELLE FORMULE SOSTITUTIVE. IMPATTO SULLA CRESCITA E PROFILO PLASMATICO DELLE PROTEINE.
Tesi di Dottorato
Data di Pubblicazione:
2012
Citazione:
ALLERGIA ALLE PROTEINE DEL LATTE VACCINO E IMPIEGO DELLE FORMULE SOSTITUTIVE. IMPATTO SULLA CRESCITA E PROFILO PLASMATICO DELLE PROTEINE / M. Mandelli ; tutor: E. Riva ; coordinatore: A. Pagani. Universita' degli Studi di Milano, 2012 Feb 27. 24. ciclo, Anno Accademico 2011.
Abstract:
Background:
Extensively hydrolyzed formula (eHF) is the first-line therapy in cow’s milk protein allergy.
Aims of the study:
We studied growth and plasmatic protein profile, depending on the different formula employed.
Materials and methods:
We selected 40 children with cow’s milk protein allergy. Diagnosis was made by skin prick test and double-blind placebo-controlled food challenge. Children were fed with soya protein-based or hydrolyzed rice protein-based or extensively hydrolyzed casein formula. The sample was analyzed at the 6th (t0) and 12th (t1) months of life: anthropometric parameters, plasmatic levels of total proteins, albumin, prealbumin, and retinol binding protein were collected.
Results:
The comparison among the groups fed with the different formulas didn’t show a gap of weight z-score, length z-score and BMI z- score at t0 and t1. We found a positive trend of growth in children fed with rice protein-based formula. The plasmatic protein profiles among the three groups weren’t statistically different (p<0,05). The mean of plasmatic level of pre-albumin of the two groups fed with eHF is higher than the one of the group fed with soya protein-based formula, especially rice protein-based formula at t0.
Conclusions:
Children fed with eHF show a positive trend of weight z-score rise. So hydrolyzed proteins could give a nutritional qualitative benefit. Each formula ensures a good growth, but no one is the best, in spite of a positive trend of eHF, especially the rice-based one.
Tipologia IRIS:
Tesi di dottorato
Keywords:
eHF ; exstensively hydrolized formula ; cow's milk allergy ; plasmatic protein ; infants' growth
Elenco autori:
M. Mandelli
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