Rare subtypes of BK virus are viable and frequently detected in renal transplant recipients with BK virus-associated nephropathy
Articolo
Data di Pubblicazione:
2010
Citazione:
Rare subtypes of BK virus are viable and
frequently detected in renal transplant recipients with BK virus-associated
nephropathy / S. Tremolada, S. Akan, J. Otte, K. Khalili, P. Ferrante, P.R. Chaudhury, E.S. Woodle, J. Trofe-Clark, M.K. White, J. Gordon. - In: VIROLOGY. - ISSN 0042-6822. - 404:2(2010), pp. 312-318. [10.1016/j.virol.2010.05.012]
Abstract:
BK virus-associated nephropathy (BKVN) occurs in up to 5% of kidney transplants and is a significant cause of graft loss. Four major subtypes of BKV have been described, with the vast majority of individuals persistently infected with BKV Type I (> 80% of the population). Sequencing of BKV isolates subcloned from BKVN patients revealed a high percentage of variants in the urine (40%) in the VP1 subtyping region. In vitro analysis of several viral variants revealed that all variants recovered from the urine of BKVN patients produced infectious viral particles and were replication competent in cell culture while some of the variants induced cytopathic changes in infected cells when compared to the major BKV subtype, VP1 Type I. These results suggest that rare BKV VP1 variants are more frequently associated with disease and that some variants could be more cytopathic than others in renal transplant recipients.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
BK virus; BKV; Kidney transplant; Polyomavirus-associated nephropathy
Elenco autori:
S. Tremolada, S. Akan, J. Otte, K. Khalili, P. Ferrante, P.R. Chaudhury, E.S. Woodle, J. Trofe Clark, M.K. White, J. Gordon
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