Cross talking molecular mechanisms in the failing heart : present and future targets of medical therapy
Articolo
Data di Pubblicazione:
2008
Citazione:
Cross talking molecular mechanisms in the failing heart : present and future targets of medical therapy / L.C. Ventura Gregorini. - In: CARDIOLOGY INTERNATIONAL. - ISSN 1468-8581. - 2008:(2008 Sep 01), pp. 83-89.
Abstract:
The old heart failure (HF) treatments that increased contractility have generally increased also
mortality, whereas neurohumoral antagonism has successfully improved survival. Nevertheless death
rate and disability remains a major social problem, mainly for patients’ undertreatment, either due to
late treatment initiation, inappropriate dosages, or lack of persistence for possible side effects. This
brief review will address the neurohumoral overdrive that makes heart fail and triggers most, if not all
changes in molecular mechanisms recently demonstrated to occur in HF syndrome. This review has
also the scope of drawing the attention of cardiologists on the Guidelines suggestions in order to
prescribe the drugs that restore a normal adrenergic receptors density thus providing a simultaneous
improvement in other interdependent mechanisms.
Molecular mechanisms related with the increase in circulating neurohormones and some
exciting novel heart failure therapies, such as replacement of the ischemic or failing cells with new
cardiomyocytes from stem cells, and the changes of adrenergic signaling by selectively modulating
specific molecules will briefly be taken into account.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
heart failure ; molecular mechanisms
Elenco autori:
L.C. Ventura Gregorini
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