Data di Pubblicazione:
2010
Citazione:
Aminoquinoline-based Ruthenium catalyst for reduction of ketones by hydrogen transfer / E. Cesarotti, I. Rimoldi, D.S. Zerla. ((Intervento presentato al 38. convegno Congresso Nazionale della Divisione di chimica Inorganica della Società Chimica Italiana tenutosi a Trieste nel 2010.
Abstract:
1. Introduction
Asymmetric reduction of C=O and C=N bonds to give chiral alcohols and amines is one of the more relevant applications of transition metal catalysis [1]. A striking improvement in hydrogenation or reduction by hydrogen transfer is due to Noyori and more recently to Rigo and co-workers with the development of Ru(II) catalysts bearing chiral diamine ligands [2].
2. Results and Discussion
Here we present our results in hydrogen transfer reduction of aryl ketones with (S)- or (R)-8-amino-5,6,7,8-tetrahydroquinoline (hereafter defined CAMPY).
The diphoshines (the counter ligands) used are the achiral triphenylphosphine, DPPB, DPPP and chiral BDPP, BDPH and Zedphos [3]. CAMPY is characterized by the presence of a fused ring; we will discuss the effects of such rigidity on matching/mismatching with the chiral diphosphines and the chirality at the metal centre on both enantioselectivity and activity.
3. References
[1] Asymmetric Catalysis on Industrial scale; H.U.Blase, E.Schmidt Eds, Wiley-VCH 2004
[2] P.Rigo, W.Baratta; Eur.J.Inorg.Chem. 2008, 4041.
[3] E.Cesarotti, I.Rimoldi, P.Spalluto, F.Demartin; Tetrahedon: Asimmetry, 2007, 1278.
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Elenco autori:
E. Cesarotti, I. Rimoldi, D.S. Zerla
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