High-Dose Ibuprofen for Patent Ductus Arteriosus in Extremely Preterm Infants : A Randomized Controlled Study
Articolo
Data di Pubblicazione:
2012
Citazione:
High-Dose Ibuprofen for Patent Ductus Arteriosus in Extremely Preterm Infants : A Randomized Controlled Study / C. Dani, V. Vangi, G. Bertini, S. Pratesi, I. Lori, F. Favelli, R. Ciuti, A. Bandinelli, C. Martano, P. Murru, H. Messner, F. Schena, F. Mosca. - In: CLINICAL PHARMACOLOGY & THERAPEUTICS. - ISSN 0009-9236. - 91:4(2012), pp. 590-596.
Abstract:
Our aim was to assess the hypothesis that a high-dose regimen of ibuprofen is more effective than the standard-dose regimen in closing patent ductus arteriosus (PDA) without increasing adverse effects. Infants of gestational age <29 weeks, with respiratory distress syndrome (RDS) and echocardiographic evidence of significant PDA at 12-24 h of life, were randomized to receive a standard (10-5-5 mg/kg/day) or high-dose (20-10-10 mg/kg/day) course of ibuprofen. We studied 70 infants, 35 of whom received the standard dose of ibuprofen and the other 35 the high dose. Of the infants treated with the standard-dose regimen, 37% had persistent PDA as compared with 14% of those treated with the high-dose regimen (P = 0.03). No differences in the occurrence of adverse effects were observed between the two groups. The high-dose ibuprofen regimen is more effective than the standard-dose regimen in closing PDA in preterm infants <29 weeks of gestation without increasing the adverse effect rate.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
C. Dani, V. Vangi, G. Bertini, S. Pratesi, I. Lori, F. Favelli, R. Ciuti, A. Bandinelli, C. Martano, P. Murru, H. Messner, F. Schena, F. Mosca
Link alla scheda completa: