Glucosylceramide Synthase protects Glioblastoma cells against autophagic and apoptotic death induced by temozolomide and paclitaxel
Articolo
Data di Pubblicazione:
2012
Citazione:
Glucosylceramide Synthase protects Glioblastoma cells against autophagic and apoptotic death induced by temozolomide and paclitaxel / P. Giussani, R. Bassi, V. Anelli, L. Brioschi, F. De Zen, E. Riccitelli, M. Caroli, R. Campanella, S.M. Gaini, P. Viani, L. Riboni. - In: CANCER INVESTIGATION. - ISSN 0735-7907. - 30:1(2012), pp. 27-37.
Abstract:
Glioblastoma is a deadly cancer with intrinsic chemoresistance. Understanding this property will aid in therapy. Glucosylceramide synthase (GCS) is associated with resistance and poor outcome; little is known about glioblastomas. In glioblastoma cells, temozolomide and paclitaxel induce ceramide increase, which in turn promotes cytotoxicity. In drug-resistant cells, both drugs are unable to accumulate ceramide, increased expression and activity of GCS is present, and its inhibitors hinder resistance. Resistant cells exhibit cross-resistance, despite differing in marker expression, and cytotoxic mechanism. These findings suggest that GCS protects glioblastoma cells against autophagic and apoptotic death, and contributes to cell survival under chemotherapy.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Autophagy; Ceramide; Glioblastoma; Glucosylceramide synthase; Temozolomide
Elenco autori:
P. Giussani, R. Bassi, V. Anelli, L. Brioschi, F. De Zen, E. Riccitelli, M. Caroli, R. Campanella, S.M. Gaini, P. Viani, L. Riboni
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