Carotid versus Coronary Stent Revascularization: Comparison of the Platelet Activation Profile
Poster
Data di Pubblicazione:
2010
Citazione:
Carotid versus Coronary Stent Revascularization: Comparison of the Platelet Activation Profile / M. Brambilla, P. Montorsi, E. Tirloni, D. Trabattoni, S. Ghulam Ali, P. Canzano, A. Bartorelli, E. Tremoli, M. Camera. - In: BLOOD TRANSFUSION. - ISSN 1723-2007. - 8:Suppl. 4(2010 Dec), pp. s127-s127. ((Intervento presentato al 21. convegno Congresso Nazionale SISET tenutosi a Bologna nel 2010.
Abstract:
Platelet activation occurs in both coronary and carotid artery
stenting as a result of vessel wall damage and subendothelium
exposure. The dual antiplatelet regimen has a significant
impact on reducing stent thrombosis and adverse outcomes.
Whether differences exist in the degree of platelet activation
among stent-treated coronary and carotid vessel is not known.
Aim To compare platelet activation in patients who underwent
carotid versus coronary revascularization.
Methods 20 patients with high-grade carotid artery stenosis
and 20 stable angina patients who underwent revascularization
with bare metal stent implantation were studied. To assess
platelet function, blood was withdrawn 1 month (T1) after
stenting procedure and 2 months after thienopyridine
discontinuation (T2). Platelet activation markers (PAC1,
CD62 and Tissue Factor [TF] and the percentage of monocyteplatelet
aggregates [MPA]) were assessed by whole blood
flow cytometry in resting conditions and upon in vitro ADP
stimulation.
Results At T1, CD62 and PAC1 positive (+) platelets were
comparable in carotid and coronary-treated patients. By
contrast, TF+ platelets as well as TF+ MPA were 3 fold higher
in coronary vs. carotid-treated patients, both under resting
conditions and upon ADP stimulation (p<0.001). At T2, the
platelet activation profile was comparable to that observed at
T1, with TF+ platelets and TF+ MPA being still significantly
higher (2-3 fold) in coronary vs. carotid-treated patients, both
under resting conditions and upon ADP stimulation (p<0.01).
No significant differences in the platelet activation markers
expression were observed between T1 and T2 both in carotidas
well as in coronary-treated patients.
Conclusion Significant higher levels of TF+ platelets and TF+
MPA were observed in peripheral blood of coronary patients
who underwent revascularization with stent implantation
compared to patients with carotid artery stenting, both 1 month
after stenting and 2 months after thienopyridine discontinuation.
This prothrombotic platelet phenotype may have implications for thrombotic complications in coronary patients.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
platelet activation ; carotid stenting ; coronary stenting
Elenco autori:
M. Brambilla, P. Montorsi, E. Tirloni, D. Trabattoni, S. Ghulam Ali, P. Canzano, A. Bartorelli, E. Tremoli, M. Camera
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