Data di Pubblicazione:
2010
Citazione:
Hypothalamic stem cells: towards a cellular approach to neuroendocrine diseases? / R. Maggi, A.M. Cariboni. - In: ACTA PHYSIOLOGICA. - ISSN 1748-1708. - 200:Suppl. 681(2010 Sep), pp. 55-55. ((Intervento presentato al 61. convegno National Congress of the Italian Physiological Society tenutosi a Varese nel 2010.
Abstract:
The mammalian hypothalamus is involved in regulating numerous physiological
functions; however, the molecular pathways that mediate hypothalamic
development are largely unknown. The study of neural stem cells (NSC) offers a
useful model to investigate such mechanisms. Neurospheres of NSC from both
fetal and adult rat hypothalami able to differentiate into glia and neurons with
neuroendocrine markers, have been recently isolated. However, we have setup a
stable cell line of NSC from E12 fetal mouse hypothalamus. The cell line (AC1)
grows as a monolayer in a defined medium enriched in FGF-2 and EGF. AC1
cells express stemness, neuronal, but not astrocytic markers. The study on AC1
cells has been focused on the expression of hypothalamic patterning genes and
the ability to develop neuroendocrine lineages in vitro. AC1 cells may therefore
help to elucidate specific physiological hypothalamic processes and offer a
valuable tool to develop a future cellular approach to neuroendocrine disorders
(i.e., diabetes insipidus, obesity, Prader-Willi syndrome, etc.).
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
neuron ; precursors ; hypothalamus ; neuroendocrinology ; stem cells
Elenco autori:
R. Maggi, A.M. Cariboni
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