Lung cancer risk prediction to select smokers for screening CT : a model based on the Italian COSMOS trial
Articolo
Data di Pubblicazione:
2011
Citazione:
Lung cancer risk prediction to select smokers for screening CT : a model based on the Italian COSMOS trial / P. Maisonneuve, V. Bagnardi, M. Bellomi, L. Spaggiari, G. Pelosi, C. Rampinelli, R. Bertolotti, N. Rotmensz, J.K. Field, A. De Censi, G. Veronesi. - In: CANCER PREVENTION RESEARCH. - ISSN 1940-6207. - 4:11(2011 Nov), pp. 1778-1789.
Abstract:
Screening with low-dose helical computed tomography (CT) has been shown to
significantly reduce lung cancer mortality but the optimal target population and time interval to subsequent screening are yet to be defined. We developed two models to stratify individual smokers according to risk of developing lung cancer. We first used the number of lung cancers
detected at baseline screening CT in the 5203 asymptomatic participants of the COSMOS trial to recalibrate the Bach model, which we propose using to select smokers for screening. Next we incorporated lung nodule characteristics and presence of emphysema identified at baseline CT into the Bach model and propose the resulting multivariable model to predict lung cancer risk in screened smokers after baseline CT. Age and smoking exposure were the main determinants of lung cancer risk. The recalibrated Bach model accurately predicted lung cancers detected during the
first year of screening. Presence of non-solid nodules (RR=10.1, 95% CI=5.57-18.5), nodule size >8 mm (RR=9.89, 95% CI=5.84-16.8) and emphysema (RR=2.36, 95% CI=1.59-3.49) at baseline CT were all significant predictors of subsequent lung cancers. Incorporation of these variables into
the Bach model increased the predictive value of the multivariable model (c-index=0.759, internal validation). The recalibrated Bach model appears suitable for selecting the higher risk population
for recruitment for large-scale CT screening. The Bach model incorporating CT findings at baseline screening could help defining the time interval to subsequent screening in individual participants.
Further studies are necessary to validate these models.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
low-dose CT; cost-effectiveness analysis; spiral computed-tomography; air-flow obstruction; ground-glass opacity; breast-cancer; adult smokers; early-stage; emphysema; validation
Elenco autori:
P. Maisonneuve, V. Bagnardi, M. Bellomi, L. Spaggiari, G. Pelosi, C. Rampinelli, R. Bertolotti, N. Rotmensz, J.K. Field, A. De Censi, G. Veronesi
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