Global population structure of Aspergillus terreus inferred by ISSR typing reveals geographical subclustering
Articolo
Data di Pubblicazione:
2011
Citazione:
Global population structure of Aspergillus terreus inferred by ISSR typing reveals geographical subclustering / C.O.S. Neal, A.O. Richardson, S.F. Hurst, A.M.Tortorano, M.A. Viviani, D.A. Stevens, S.A. Balajee. - In: BMC MICROBIOLOGY. - ISSN 1471-2180. - 11(2011), pp. 203.1-203.7.
Abstract:
Background: Aspergillus terreus causes invasive aspergillosis (IA) in immunocompromised individuals and can be
the leading cause of IA in certain medical centers. We examined a large isolate collection (n = 117) for the
presence of cryptic A. terreus species and employed a genome scanning method, Inter-Simple Sequence Repeat
(ISSR) PCR to determine A. terreus population structure.
Results: Comparative sequence analyses of the calmodulin locus revealed the presence of the recently recognized
species A. alabamensis (n = 4) in this collection. Maximum parsimony, Neighbor joining, and Bayesian clustering of
the ISSR data from the 113 sequence-confirmed A. terreus isolates demonstrated that one clade was composed
exclusively of isolates from Europe and another clade was enriched for isolates from the US.
Conclusions: This study provides evidence of a population structure linked to geographical origin in A. terreus.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Microsatellite Repeats ; Aspergillosis ; Aspergillus ; Bacterial Typing Techniques ; Europe ; Humans ; Phylogeny ; Phylogeography ; United States
Elenco autori:
C.O.S. Neal, A.O. Richardson, S.F. Hurst, A.M.Tortorano, M.A. Viviani, D.A. Stevens, S.A. Balajee
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