Role of subunit composition in determining acetylcholine receptor degradation rates in rat myotubes
Articolo
Data di Pubblicazione:
1998
Citazione:
Role of subunit composition in determining acetylcholine receptor degradation rates in rat myotubes / C. Sala, M. Francolini, D. Di Mauro, G. Fumagalli. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 256:1(1998 Oct 30), pp. 1-4.
Abstract:
During neuromuscular junction maturation, the rapidly degrading receptors (Rr; t1/2 approximately equal to 1 day) are replaced by metabolically stable molecules (Rs; t1/2 approximately equal to 10 days). Rr and Rs do not interconvert, are differently regulated after denervation in adult muscle and are endowed of unique responses to stabilizing agents. In cultured rat myotubes all the epsilon subunit-containing acetylcholine receptors (epsilon-AchRs) are of the Rs type. In the present study we show that Rs exist also in absence of epsilon-AChR and that nonepsilon-(presumably gamma-)AChRs can be included in the Rs pool when epsilon-AChR expression is low. The data indicate that Rs metabolic properties are independent of AChR subunit composition and that epsilon subunit is a signal to efficiently sort AChR molecules to the Rs pool.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Rats ; Animals ; Rats, Sprague-Dawley ; Neuromuscular Junction ; Cells, Cultured ; Kinetics ; Isomerism ; Bungarotoxins ; Precipitin Tests ; Receptors, Cholinergic ; Muscle, Skeletal
Elenco autori:
C. Sala, M. Francolini, D. Di Mauro, G. Fumagalli
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