Data di Pubblicazione:
2011
Citazione:
Multiple sclerosis : BAFF and CXCL13 in cerebrospinal fluid / S. Ragheb, Y. Li, K. Simon, S. Vanhaerents, D. Galimberti, M.A. De Riz, C. Fenoglio, E.A. Scarpini, R. Lisak. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - 17:7(2011), pp. 819-829. [10.1177/1352458511398887]
Abstract:
Background: There is increasing evidence of B-cell involvement in the pathogenesis of multiple sclerosis (MS). B-cell activating factor (BAFF) has an essential role in B-cell homeostasis. The chemokine CXCL13 has an important role in the formation and maintenance of B-cell follicles.
Objective: To measure BAFF and CXCL13 levels in the cerebrospinal fluid (CSF) of patients with MS compared to patients with other neurological diseases.
Methods: Cytokine/chemokine levels were measured by an enzyme-linked immunosorbent assay (ELISA).
Results: In MS patients, BAFF levels were highest in patients with secondary progressive disease, and were higher during relapse in patients with relapsing-remitting and secondary progressive disease. CXCL13 levels were also higher during relapse. There was a positive correlation between CXCL13 and the IgG index, and an inverse correlation between BAFF and the IgG index. The implications of this finding are discussed.
Conclusion: During relapse, we found various positive correlations between BAFF, CXCL13 and the cytokines IL-6 and IL-10. These findings show that molecules that are essential for B-cell recruitment, survival, maturation and function may be working in concert to affect B-cell homeostasis in MS and contribute to the pathophysiology of the disease.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
BAFF; cerebrospinal fluid; CXCL13; IgG index; multiple sclerosis
Elenco autori:
S. Ragheb, Y. Li, K. Simon, S. Vanhaerents, D. Galimberti, M.A. De Riz, C. Fenoglio, E.A. Scarpini, R. Lisak
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