Consensus document on controversial issues for the treatment of hospital-associated pneumonia
Articolo
Data di Pubblicazione:
2010
Citazione:
Consensus document on controversial issues for the treatment of hospital-associated pneumonia / F. Franzetti, M. Antonelli, M. Bassetti, F.B.A. Blasi, M. Langer, F. Scaglione, E. Nicastri, F.N. Lauria, G. Carosi, M. Moroni, G. Ippolito, GISIG Working Group on hospital-associated pneumonia. - In: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. - ISSN 1201-9712. - 14:Suppl 4(2010), pp. S55-S65. ((Intervento presentato al convegno Controversial Issues of Severe Bacterial Infections due to Multidrug-resistant Gram-positive Bacteria : Recommendations from GISIG 3 tenutosi a Roma nel 2009 [10.1016/j.ijid.2010.05.008].
Abstract:
Background: Hospital-associated pneumonia (HAP) remains an important cause of morbidity and mortality despite advances in antimicrobial therapy. Many aspects of the treatment of HAP caused by multi-resistant Gram-positive microorganisms have been extensively studied, but controversial issues
remain.
Controversial issues: The aim of this GISIG (Gruppo Italiano di Studio sulle Infezioni Gravi) working group – a panel of multidisciplinary experts – was to define recommendations for some controversial issues
using an evidence-based and analytical approach. The controversial issues were: (1) Is combination antibiotic therapy or monotherapy more effective in the treatment of HAP? (2) What role do pharmacokinetic/ pharmacodynamic antibiotic features have as a guide in the selection of treatment for
HAP? (3) Is a de-escalation approach for the management of HAP effective? An analysis of the studies published up until April 2009 is presented and discussed in detail.
Methods: A systematic literature search using PubMed, MEDLINE, and EMBASE databases and the Cochrane Library was performed. A matrix was created to extract evidence from original studies using the CONSORT method to evaluate randomized clinical trials and the Newcastle–Ottawa Quality Assessment Scale for case–control studies, longitudinal cohorts, and retrospective studies. The GRADE method for grading quality of evidence was applied.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Nosocomial pneumonia ; Health care-associated pneumonia ; Methicillin-resistant staphylococci
Elenco autori:
F. Franzetti, M. Antonelli, M. Bassetti, F.B.A. Blasi, M. Langer, F. Scaglione, E. Nicastri, F.N. Lauria, G. Carosi, M. Moroni, G. Ippolito, G. Working Group on hospital associated pneumonia
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