Pharmacokinetic/pharmacodynamic (PK/PD) considerations in the management of Gram-positive bacteraemia
Articolo
Data di Pubblicazione:
2010
Citazione:
Pharmacokinetic/pharmacodynamic (PK/PD) considerations in the management of Gram-positive bacteraemia / F. Scaglione. - In: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. - ISSN 0924-8579. - 36:suppl. 2(2010), pp. S33-S39. ((Intervento presentato al 4. convegno European Conference on Bloodstream Infections tenutosi a Athens nel 2010.
Abstract:
Bloodstream infections are amongst the most serious infections of hospitalised patients and are associated with high mortality, especially amongst those with severe sepsis and septic shock. A range of organ dysfunctions, together with drug interactions and other therapeutic interventions (e.g. haemodynamically
active drugs and continuous renal replacement therapies) may have a strong impact on antimicrobial drug pharmacokinetics in critically ill patients. Intrinsic pharmacokinetic (PK) and pharmacodynamic (PD) properties are the major determinants of the in vivo efficacy of antimicrobial agents. Knowledge
of PK/PD parameters is essential in facilitating the translation of microbiological activity into clinical
situations and ensuring a successful outcome. This review analyses the typical patterns of antimicrobial activity of classes of agent commonly utilised against Gram-positive pathogens in hospital settings, and their corresponding PK/PD parameters, focusing on the PK/PD dosing approach.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
F. Scaglione
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