Interaction between ticlopidine or warfarin or cardioaspirin with a highly standardized deterpened Ginkgo biloba extract (VR456) in rat and human
Articolo
Data di Pubblicazione:
2010
Citazione:
Interaction between ticlopidine or warfarin or cardioaspirin with a highly standardized deterpened Ginkgo biloba extract (VR456) in rat and human / F. Di Pierro, F. Rinaldi, M. Lucarelli, G.B. Rossoni. - In: ACTA BIO-MEDICA DE L'ATENEO PARMENSE. - ISSN 0392-4203. - 81:3(2010), pp. 196-203.
Abstract:
Ginkgo biloba is available in Europe as an over-the-counter drug and it is reported to cause hemorrhage
when co-administered with other anti-platelet agents.We set out to study the interactions of ticlopidine
with Ginkgo biloba extract or VR456, a new highly standardized deterpened extract from Ginkgo biloba
leaves.MaleWistar rats were used to study the effects of ticlopidine (50-100 mg/kg/day), given alone and
in combination for 5 days with Ginkgo biloba extract (50 mg/kg/day) or VR456 (50 mg/kg/day), on bleeding
time and ex vivo ADP-induced platelet aggregation measurements. In addition, human studies were performed
with the compounds under investigation.Combined treatment of ticlopidine and undeterpened Ginkgo
biloba extract increased anti-platelet effect and prolonged the bleeding time in the rat.On the contrary, the
combination treatment of ticlopidine and VR456 increased anti-platelet effect but did not prolong bleeding
time.Moreover, daily administration of 360 mg of VR456 for 14 days to ticlopidine-treated humans did not
highlight any unwanted effect and did not alter PT/INR and PTT parameters. Same results have been also
obtained in warfarin or in cardioaspirin-treated patients.These data point out the clear role played by the terpenoid,
PAF-antagonist fraction of Ginkgo biloba extract in affecting bleeding risk in anticoagulant-treated
subjects and suggest VR456 as a possible option treatment in geriatric people subjected to anticoagulant treatment
where the use of standard Ginkgo biloba extracts are discouraged
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cardioaspirin; Ginkgo biloba; Human; Rat; Ticlopidine; VR456; Warfarin
Elenco autori:
F. Di Pierro, F. Rinaldi, M. Lucarelli, G.B. Rossoni
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