Intraobserver and interobserver variability in the calculation of apparent diffusion coefficient (ADC) from diffusion-weighted magnetic resonance imaging (DW-MRI) of breast tumours
Articolo
Data di Pubblicazione:
2011
Citazione:
Intraobserver and interobserver variability in the calculation of apparent diffusion coefficient (ADC) from diffusion-weighted magnetic resonance imaging (DW-MRI) of breast tumours / G. Petralia, L. Bonello, P. Summers, L. Preda, A. Malasevschi, S. Raimondi, R. Di Filippi, M. Locatelli, G. Curigliano, G. Renne, M. Bellomi. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - 116:3(2011 Jan 12), pp. 466-476. [10.1007/s11547-011-0616-z]
Abstract:
Purpose
This study evaluated intraobserver and interobserver variability in the measurement of apparent diffusion coefficient (ADC) values in breast carcinomas.
Materials and methods
Twenty-eight patients with solid breast lesions >10 mm underwent conventional contrast-enhanced magnetic resonance imaging (MRI) and diffusion-weighted MRI (DW-MRI). Two observers (expert and trainee) segmented the lesion from the surrounding breast tissue on DW images with high b-value (1,000 s/mm2). This analysis was repeated by the expert reader after 6 months. Volumes were analysed to obtain mean, median and standard deviation (SD) of the ADC values. Interobserver and intraobserver variation was analysed using the Bland-Altman graph.
Results
All lesions were breast carcinomas, with a mean ADC value of 1.07 × 10−3 mm2/s. The mean of the differences was 0.012 × 10−3 mm2/s, corresponding to an intraobserver variability of 1.1% (limits of agreement: −5%/+8%). The mean interobserver difference was 0.022 × 10−3 mm2/s, corresponding to an interobserver variability of 2% (limits of agreement: −9%/+14%).
Conclusions
We found a low intraobserver and interobserver variability in calculating ADC in breast carcinomas, which supports its potential use in routine clinical practice.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
G. Petralia, L. Bonello, P. Summers, L. Preda, A. Malasevschi, S. Raimondi, R. Di Filippi, M. Locatelli, G. Curigliano, G. Renne, M. Bellomi
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