EpiWEAT: a new digital assessment tool for epigenetic studies

Introduction. Intimate partner violence (IPV) profoundly impacts women’s health, increasing
the risk of chronic and non-communicable diseases. Recent findings underscore
the promise of epigenetic indicators to uncover the enduring effects of trauma on the
human genome, especially concerning stress-related conditions such as post-traumatic
stress disorder (PTSD).
Objectives. To evaluate the lasting health impacts of violence against women, developing
a digital tool specifically structured to consolidate crucial details about the contexts of
violence, the relationship between victim and perpetrator, and health outcomes.
Methods. A Microsoft Forms-based questionnaire was developed, organized into nine
sections addressing socio-personal information, external conditions of violence, health
statuses, and psychological evaluations, incorporating PTSD assessment via the International
Trauma Questionnaire and depression measurement through the Center for epidemiologic
studies depression scale revised (CESD-R) module. Data is securely archived,
and participation includes optional consent for epigenetic analysis through blood samples.
Conclusions. The assessment tool presents a thorough tool for gathering information
on IPV, evaluating health outcomes, and identifying PTSD and depression in survivors.
It also aids in the collection of biological specimens for epigenetic exploration. This instrument
could enhance intervention strategies and contribute to precision medicine
methodologies, facilitating early detection of chronic health risks in women who have
experienced violence.