Antidepressant treatments change 5-HT2C receptor mRNA expression in rat prefrontal/frontal cortex and hippocampus
Articolo
Data di Pubblicazione:
2011
Citazione:
Antidepressant treatments change 5-HT2C receptor mRNA expression in rat prefrontal/frontal cortex and hippocampus / A. Barbon, C. Orlandi, L. La Via, L. Caracciolo, D. Tardito, L. Musazzi, A. Mallei, M. Gennarelli, G. Racagni, M. Popoli, S. Barlati. - In: NEUROPSYCHOBIOLOGY. - ISSN 0302-282X. - 63:3(2011), pp. 160-168. [10.1159/000321593]
Abstract:
Compelling evidence would suggest the involvement of the serotonin 2C receptor in the pathophysiology of affective disorders and in the action of antidepressants. We analyzed the time course of 5-HT2C receptor (5-HTR2C) mRNA expression during antidepressant treatment in the prefrontal/frontal cortex (P/FC) and in the hippocampus (HC) of rats chronically treated with fluoxetine (a selective serotonin reuptake inhibitor) and reboxetine (a selective noradrenaline reuptake inhibitor). We also analyzed the 5-HTR2C RNA-editing levels at the sites called A, B, C, C' and D, which are known to modulate 5-HTR2C receptor function.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
5-HTR2C; Antidepressants; Gene expression; Major depressive disorder; RNA editing
Elenco autori:
A. Barbon, C. Orlandi, L. La Via, L. Caracciolo, D. Tardito, L. Musazzi, A. Mallei, M. Gennarelli, G. Racagni, M. Popoli, S. Barlati
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