Synthesis, structural characterization, formation constants and in vitro cytotoxicity of phenanthroline and imidazolidine-2-thione copper(II) complexes
Articolo
Data di Pubblicazione:
2011
Citazione:
Synthesis, structural characterization, formation constants and in vitro cytotoxicity of
phenanthroline and imidazolidine-2-thione copper(II) complexes / T. Pivetta, M.D. Cannas, F. Demartin, C. Castellano, S. Vascellari, G. Verani, F. Isaia. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 105:3(2011), pp. 329-338. [10.1016/j.jinorgbio.2010.11.017]
Abstract:
The synthesis, crystal structures, physicochemical properties and complex formation constants of [Cu(phen)2(L)]
(ClO4)2 complexes, where phen is 1,10-ortho-phenanthroline and L is a series of substituted imidazolidine-2-
thione, have been studied. Single crystal X-ray diffraction revealed a distorted trigonal–bipyramidal geometry for
all the molecules. The complex formation constants were determined in nonaqueous media by spectrophotometricmeasurements.
Testing copper(II) complexes inmouse neuroblastomaN2a cells persistently infected with
the 22L strain of the scrapie prion protein (22L-N2a) resulted in high cytotoxicity but no antiprion activity at
nontoxic doses.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Copper(II) complexes; X-ray structure; complex formation constants; cytotoxicity
Elenco autori:
T. Pivetta, M.D. Cannas, F. Demartin, C. Castellano, S. Vascellari, G. Verani, F. Isaia
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