Myocardial delayed enhancement using a single (0.1 mmol/kg) dose of gadobenate dimeglumine : contrast resolution versus intraventricular blood and viable myocardium
Articolo
Data di Pubblicazione:
2010
Citazione:
Myocardial delayed enhancement using a single (0.1 mmol/kg) dose of gadobenate dimeglumine : contrast resolution versus intraventricular blood and viable myocardium / G.D.E. Papini, S. Tritella, F. Secchi, A. Aliprandi, G. Di Leo, F. Sardanelli. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - 115:5(2010 Aug), pp. 693-701. [10.1007/s11547-010-0495-2]
Abstract:
This study was done to estimate delayed enhancement (DE) contrast resolution of infarcted myocardium (IM) relative to intraventricular blood (IB) and viable myocardium (VM) using gadobenate dimeglumine (Gd-BOPTA).
After approval from the Ethics Committee, we retrospectively evaluated 21 consecutive patients (61 +/- 10 years) with a healed myocardial infarction who underwent 1.5-T magnetic resonance (MR) imaging using an inversion-recovery-prepared turbo gradient-echo sequence 10 minutes after injection of 0.1 mmol/kg of Gd-BOPTA. Signal intensity (SI) was measured in arbitrary units (au) for IM, IB, VM, and outside the patient. Contrast-to-noise ratio (CNR) was calculated for IM to IB and IM to VM. Seven consecutive patients (59 +/- 6 years) with a healed myocardial infarction studied with similar technique but with 0.1 mmol/kg of gadoterate meglumine (Gd-DOTA) served as the control group. The Mann-Whitney U test was used to compare groups.
Mean SI of IM was 44 +/- 16 au for Gd-BOPTA and 20 +/- 6 au for Gd-DOTA (p < 0.001), that of IB 35 +/- 15 au and 14 +/- 5 au (p=0.016), and that of VM 7 +/- 3 au and 5 +/- 2 au (p=0.116), respectively. Mean IM to IB CNR was 10 +/- 7 for Gd-BOPTA and 8 +/- 5 for Gd-DOTA (p=0.836), that of IM to VM was 45 +/- 27 and 18 +/- 6, respectively (p=0.012).
Gd-BOPTA at 0.1 mmol/kg produced a higher myocardial DE and an IM to VM CNR than a single dose of Gd-DOTA. No significant difference was observed for IM to IB CNR.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cardiac magnetic resonance (CMR); Delayed enhancement (DE); Gadobenate dimeglumine (Gd-BOPTA); Gadoterate meglumine (Gd-DOTA); Myocardium
Elenco autori:
G.D.E. Papini, S. Tritella, F. Secchi, A. Aliprandi, G. Di Leo, F. Sardanelli
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