Data di Pubblicazione:
2009
Citazione:
Derivatives of 4- or 5-aminosalicylic acid / J.L. Wallace, G. Cirino, G. Caliendo, A. Sparatore, V. Santagada, S. Fiorucci.
Abstract:
The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.
Tipologia IRIS:
09 - Brevetto, privativa o norma
Keywords:
5-aminosalicylic acid derivatives; inflammatory bowel disease; irritable bowel disease; hydrogen sulfide-releasing drugs
Elenco autori:
J.L. Wallace, G. Cirino, G. Caliendo, A. Sparatore, V. Santagada, S. Fiorucci
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