Common Carotid Intima-Media Thickness in High-Risk Patients in Russia and European Populations
Articolo
Data di Pubblicazione:
2010
Citazione:
Common Carotid Intima-Media Thickness in High-Risk Patients in Russia and European Populations / I. Sobenin, V. Myasoedova, T. Kirichenko, E. Anisimova, S. Castelnuovo, M. Amato, B. Frigerio, A. Ravani, A. Orekhov, E. Tremoli, D. Baldassarre. - In: ATHEROSCLEROSIS SUPPLEMENTS. - ISSN 1567-5688. - 11:2(2010), pp. P55-P55. ((Intervento presentato al 78. convegno Congress of the European Atherosclerosis Society tenutosi a Hamburg nel 2010 [10.1016/S1567-5688(10)70254-3].
Abstract:
Background: Russia is characterized by enormously high levels of CVD
mortality and morbidity as compared to European populations. A recent
European study indicates the existence of a geographical gradient in subclinical
atherosclerosis which parallels well the North to South geographical gradient in
cardiovascular mortality described in the WHO Europe database.
Aim: To compare the cIMT distribution of a selected high risk populations
recruited in Moscow (n = 472) with that of the European samples described
in the IMPROVE study.
Patients and Methods: Asymptomatic men and women (55−79 yrs) with at
least three VRFs were eligible for the Study. Different from the IMPROVE
Study, ultrasonic scans were focused on the distal centimeter of common carotid
arteries only. IMT measurements were performed in Monzino Cardiology Center
by a qualified reader using Mat’h software.
Results: The analysis carried out adding the group from Moscow to the
IMPROVE study groups revealed that the correlation between the standardized
mortality ratio for ischemic heart disease obtained from the WHO Europe
database and cIMT is not linear (R-square 0.86, p < 0.001 for logarithmic
correlation). The mean (95% CI) cIMT value was 0.82 (0.81–0.85) mm in
Moscow and 0.73 (0.72–0.74) mm in Milan (p < 0.001).
Conclusion: Cardiovascular mortality in Russia is only partially explained by
a higher atherosclerosis risk profile; cIMT plays a role as the risk factor for
atherosclerotic disease, as well as for the striking difference in cardiovascular
mortality between EU and Russia.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
I. Sobenin, V. Myasoedova, T. Kirichenko, E. Anisimova, S. Castelnuovo, M. Amato, B. Frigerio, A. Ravani, A. Orekhov, E. Tremoli, D. Baldassarre
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