Abnormalities of hemostasis and bleeding in chronic liver disease : the paradigm is challenged
Articolo
Data di Pubblicazione:
2010
Citazione:
Abnormalities of hemostasis and bleeding
in chronic liver disease : the paradigm is challenged / A. Tripodi, M. Primignani, P. M. Mannucci. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - 5:1(2010 Feb), pp. 7-12.
Abstract:
Chronic liver disease is characterized by a global hemostatic defect including platelet-vessel wall interaction (primary hemostasis), coagulation and fibrinolysis that may cause abnormalities of the relevant laboratory tests. The causal relationship between abnormal tests and bleeding has been widely accepted, despite the fact that abnormal tests are poorly associated with the timing and incidence of actual bleeding. In this article, we review recent evidence from the literature that disputes the above paradigm, and opens new venues for laboratory/clinical research and patient management in this field.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Acquired coagulation disorders; APTT; Cirrhosis; PT; Thrombin generation
Elenco autori:
A. Tripodi, M. Primignani, P. M. Mannucci
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