Data di Pubblicazione:
2024
Citazione:
The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer / F. Fontana, G. Giannitti, S. Marchesi, P. Limonta. - In: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES. - ISSN 1449-2288. - 20:8(2024), pp. 3113-3125. [10.7150/ijbs.89942]
Abstract:
Aberrant activation of the PI3K/Akt pathway commonly occurs in cancers and correlates with multiple aspects of malignant progression. In particular, recent evidence suggests that the PI3K/Akt signaling plays a fundamental role in promoting the so-called aerobic glycolysis or Warburg effect, by phosphorylating different nutrient transporters and metabolic enzymes, such as GLUT1, HK2, PFKB3/4 and PKM2, and by regulating various molecular networks and proteins, including mTORC1, GSK3, FOXO transcription factors, MYC and HIF-1α. This leads to a profound reprogramming of cancer metabolism, also impacting on pentose phosphate pathway, mitochondrial oxidative phosphorylation, de novo lipid synthesis and redox homeostasis and thereby allowing the fulfillment of both the catabolic and anabolic demands of tumor cells. The present review discusses the interactions between the PI3K/Akt cascade and its metabolic targets, focusing on their possible therapeutic implications.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Akt; PI3K; Warburg effect; aerobic glycolysis; cancer metabolism
Elenco autori:
F. Fontana, G. Giannitti, S. Marchesi, P. Limonta
Link alla scheda completa:
Link al Full Text: