Data di Pubblicazione:
2010
Citazione:
Prevention of contrast-induced nephropathy: a single center randomized study / D. Castini, S. Lucreziotti, L. Bosotti, D. Salerno Uriarte, C. Sponzilli, A. Verzoni, F. Lombardi. - In: CLINICAL CARDIOLOGY. - ISSN 0160-9289. - 33:3(2010), pp. E63-E68. [10.1002/clc.20576]
Abstract:
Background: Contrast-induced nephropathy (CIN) is the third cause of acute deterioration of renal function in hospitalized patients. Hypothesis: The purpose of the study was to compare the efficacy of saline infusion, saline infusion plus N-acetylcysteine (NAC), and sodiumbicarbonate (SB) infusion to prevent CIN in patients undergoing coronary angiography and/or percutaneous coronary intervention. Methods: We prospectively studied 156 patients with a baseline creatinine level ≥1.2mg/dL. The primary endpoint was the development of CIN, defined as an increase in serum creatinine concentration ≥25% over the baseline value within 5 days fromcontrast exposure. Results: Contrast-induced nephropathy developed in 23 patients (14.7%). Incidence of the primary endpoint was similar in the 3 groups of treatment, occurring in 7 patients (14%) in the saline infusion group, in 9 (17%) in the saline infusion plus NAC group, and in 7 (14%) in the SB infusion group. Conclusions: Our findings suggest that neither the addition of NAC nor the administration of SB add further benefit in CIN prevention, compared to standard hydration with isotonic saline infusion.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
D. Castini, S. Lucreziotti, L. Bosotti, D. Salerno Uriarte, C. Sponzilli, A. Verzoni, F. Lombardi
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