ORAL DELIVERY SYSTEMS INTENDED FOR COLONIC RELEASE OF INSULIN AND SELECTED FUNCTIONAL ADJUVANTS
Tesi di Dottorato
Data di Pubblicazione:
2009
Citazione:
ORAL DELIVERY SYSTEMS INTENDED FOR COLONIC RELEASE OF INSULIN AND SELECTED FUNCTIONAL ADJUVANTS / M.d. Del Curto ; tutor: Alessandra Maroni ; coordinatore: Carlo De Micheli. DIPARTIMENTO DI SCIENZE FARMACEUTICHE "PIETRO PRATESI", 2009 Dec 17. 22. ciclo, Anno Accademico 2008/2009.
Abstract:
Abstract of the PhD thesis entitled “Oral delivery systems intended for colonic release of insulin and selected functional adjuvants”
Colon delivery has gained increased attention as a potential approach to improve the oral bioavailability of peptides and proteins. In this respect, the suitability of a previously developed release platform (ChronotopicTM) was explored for the conveyance of insulin and selected functional adjuvants. The system consists of a drug core and a swellable/erodible hydroxypropyl methylcellulose (HPMC) release-controlling coating. When an outer enteric film is applied, colon delivery is obtained based on relatively consistent small intestinal transit time. Preliminarily, the compatibility of insulin with a protease inhibitor (camostat mesilate, CM) and an absorption enhancer (sodium glycocholate, NaGly) was assessed. Subsequently, differing insulin/adjuvants release patterns were pursued by properly modifying the system formulation. A concurrent liberation of these compounds was achieved after reproducible and programmable lag phases from devices in which the protein and enzyme inhibitor/absorption enhancer were included in the core unit. The possibility of timing the adjuvant release to occur prior to that of the protein, which might allow a more favorable environment to be established in advance, was then investigated. For this purpose, prototypes with a CM/NaGly interlayer enclosed between HPMC coatings with differing thicknesses were prepared that elicited flexible two-pulse release profiles.
Tipologia IRIS:
13 - Tesi di dottorato discussa entro ottobre 2010
Elenco autori:
M.D. DEL CURTO
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