Data di Pubblicazione:
2010
Citazione:
Biological variability of glycated hemoglobin / F. Braga, A. Dolci, A. Mosca, M. Panteghini. - In: CLINICA CHIMICA ACTA. - ISSN 0009-8981. - 411:21-22(2010), pp. 1606-1610. [10.1016/j.cca.2010.07.030]
Abstract:
Background: The measurement of glycated hemoglobin (HbA1c) has a pivotal role in monitoring glycemic state in diabetic patients. Furthermore, the American Diabetes Association has recently recommended the
use of HbA1c for diabetes diagnosis, but a clear definition of the clinically allowable measurement error is still lacking. Information on biological variability of the analyte can be used to achieve this goal.
Methods: We systematically reviewed the published studies on the biological variation of HbA1c to check consistency of available data in order to accurately define analytical goals.
Results: The nine recruited studies were limited by choice of analytic methodology, population selection,protocol application and statistical analyses.
Conclusions: There is an urgent need to determine biological variability of HbA1c using a specific and traceable assay, appropriate protocol and appropriate statistical evaluation of data.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Biological variability; Diabetes mellitus; Glycated hemoglobin
Elenco autori:
F. Braga, A. Dolci, A. Mosca, M. Panteghini
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