Data di Pubblicazione:
2010
Citazione:
Nfix regulates fetal specific transcription in developing skeletal muscle / G. Messina, S. Biressi, S. Monteverde, A. Magli, M. Cassano, L. Perani, E. Roncaglia, E. Tagliafico, L. Starnes, C.E. Cambpell, M. Grossi, D.J. Goldhamer, R.M. Gronostajski, G. Cossu. - In: CELL. - ISSN 0092-8674. - 140:4(2010), pp. 554-566. [10.1016/j.cell.2010.01.027]
Abstract:
Skeletal myogenesis, like hematopoiesis, occurs in successive developmental stages that involve different cell populations and expression of different genes. We show here that the transcription factor nuclear factor one X (Nfix), whose expression is activated by Pax7 in fetal muscle, in turn activates the transcription of fetal specific genes such as MCK and beta-enolase while repressing embryonic genes such as slow myosin. In the case of the MCK promoter, Nfix forms a complex with PKC theta that binds, phosphorylates, and activates MEF2A. Premature expression of Nfix activates fetal and suppresses embryonic genes in embryonic muscle, whereas muscle-specific ablation of Nfix prevents fetal and maintains embryonic gene expression in the fetus. Therefore, Nfix acts as a transcriptional switch from embryonic to fetal myogenesis.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
DEVBIO
Elenco autori:
G. Messina, S. Biressi, S. Monteverde, A. Magli, M. Cassano, L. Perani, E. Roncaglia, E. Tagliafico, L. Starnes, C.E. Cambpell, M. Grossi, D.J. Goldhamer, R.M. Gronostajski, G. Cossu
Link alla scheda completa: