Data di Pubblicazione:
2010
Citazione:
Repairing skeletal muscle : regenerative potential of skeletal muscle stem cells / F.S. Tedesco, A. Dellavalle, J. Diaz-Manera, G. Messina, G. Cossu. - In: THE JOURNAL OF CLINICAL INVESTIGATION. - ISSN 0021-9738. - 120:1(2010), pp. 11-19. [10.1172/JCI40373]
Abstract:
Skeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon satellite cells, myogenic progenitors localized between the basal lamina and the muscle fiber membrane. However, other cell types outside the basal lamina, such as pericytes, also have myogenic potency. Here, we discuss the main properties of satellite cells and other myogenic progenitors as well as recent efforts to obtain myogenic cells from pluripotent stem cells for patient-tailored cell therapy. Clinical trials utilizing these cells to treat muscular dystrophies, heart failure, and stress urinary incontinence are also briefly outlined.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Duchenne muscular-dystrophy ; stress urinary-incontinence ; bone-marrow transplantation ; myoblast transfer therapy ; ischemic-heart failure ; 1-year follow-up ; satellite cells ; self-renewal ; myogenic progenitors ; autologous transplantation
Elenco autori:
F.S. Tedesco, A. Dellavalle, J. Diaz-Manera, G. Messina, G. Cossu
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