Low-grade inflammation may play a role in the etiology of the metabolic syndrome in patients with coronary heart disease: the HIFMECH study
Articolo
Data di Pubblicazione:
2004
Citazione:
Low-grade inflammation may play a role in the etiology of the metabolic syndrome in patients with coronary heart disease: the HIFMECH study / J. S. Yudkin, I. Juhan-Vague, E. Hawe, S. E. Humphries, G. di Minno, M. Margaglione, E. Tremoli, T. Kooistra, P. E. Morange, P. Lundman, V. Mohamed-Ali, A. Hamsten; The HIFMECH Study Group. - In: METABOLISM, CLINICAL AND EXPERIMENTAL. - ISSN 0026-0495. - 53:7(2004), pp. 852-857.
Abstract:
Risk of coronary heart disease has been related to insulin resistance, but the mechanism for this is incompletely understood.
Variables attributed to insulin resistance are associated with low-grade inflammation. A case-control study was performed
of 469 male myocardial infarction (MI) survivors aged <60 years and 575 control subjects recruited from centers in northern
and southern Europe. Principal factor analysis was used to explore correlations between insulin resistance and inflammatory
variables. Three factors resulted: (a) “Metabolic Syndrome” (insulin/proinsulin/ triglyceride/body mass index [BMI]); (b)
“Inflammation” (fibrinogen/C-reactive protein [CRP]/interleukin-6 [IL-6]); and (c) “Blood Pressure” (systolic and diastolic
blood pressure). The “Metabolic Syndrome” factor was related to the “Inflammation” factor (largely independently of
obesity), the “Blood Pressure” factor, smoking, and south location (all P < .0002). There were significant relationships
between all 3 factors and case status (P < .0002). Markers of low-grade inflammation are strongly related to metabolic
syndrome variables independently of obesity. This raises the possibility that links between insulin resistance and cardiovascular
disease could, in part, represent common consequences of low-grade inflammation
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
J. S. Yudkin, I. Juhan-Vague, E. Hawe, S. E. Humphries, G. di Minno, M. Margaglione, E. Tremoli, T. Kooistra, P. E. Morange, P. Lundman, V. Mohamed-Ali, A. Hamsten; The HIFMECH Study Group
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