Data di Pubblicazione:
2010
Citazione:
Wine, sirtuins and nephroprotection: not only resveratrol / C. Mannari, A. Bertelli, G. Stiaccini, L. Giovannini. - In: MEDICAL HYPOTHESES. - ISSN 0306-9877. - 75:6(2010 Dec), pp. 636-638.
Abstract:
Resveratrol (RSV), a red wine component, and red wine itself exert cardio- and nephroprotective effects by modulating the Nitric Oxide system (NO). It has been shown that one of the main actions resulting from NO modulation is sirtuin regulation, especially SIRT-1 regulation. Elucidating both upstream and downstream molecular mechanisms of the SIRT-1 pathway is an open field of investigation that can explain its role not only in long-term processes, such as aging, but also in short-term processes, such as protection against ischemic damage.
Our hypothesis suggests the importance of investigating compounds that are routine dietary compo- nents and do not necessarily contain RSV. Their nephroprotective activity could involve not only eNOS-dependent, but also NO-dependent but eNOS-independent mechanisms, or other molecular alter- native signaling systems.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
C. Mannari, A. Bertelli, G. Stiaccini, L. Giovannini
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