Data di Pubblicazione:
2002
Citazione:
[Alveolar-capillary dysfunction in heart failure] / S. De Vita, M. Guazzi, J. Oreglia, M. Guazzi. - In: ITALIAN HEART JOURNAL. SUPPLEMENT. - ISSN 1129-4728. - 3:10(2002 Oct), pp. 1022-1026.
Abstract:
Heart failure increases the resistance to gas transfer across the alveolar-capillary interface. In different experimental conditions of vascular capillary injury, peculiar anatomical and functional abnormalities of the alveolar unit have been reported and consist of a disruption of its anatomical configuration and of a loss of fluid-flux regulation and gas exchange efficiency (i.e. "stress failure" of the alveolar-capillary membrane). In heart failure, the pathophysiological relevance of these changes has been only recently appreciated. Alveolar-capillary membrane conductance and capillary blood volume are subcomponents of lung diffusion capacity. A reduction of the former with an increase of the latter and consequent impairment of gas exchange are typical of heart failure syndrome. Alveolar-capillary membrane conductance abnormalities have been shown to be a sensitive index of the underlying lung tissue damage, bring an independent prognostic information and play a significant role in the pathogenesis of exercise limitation and ventilatory abnormalities. This review examines the current knowledge on this topic.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
S. De Vita, M. Guazzi, J. Oreglia, M. Guazzi
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