Data di Pubblicazione:
2024
Citazione:
The Impact of Antimicrobial Resistance in Cystic Fibrosis / A. Vitiello, F. Blasi, M. Sabbatucci, A. Zovi, F. Miele, A. Ponzo, R. Langella, M. Boccellino. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2240-0109. - 13:6(2024), pp. 1711.1-1711.13. [10.3390/jcm13061711]
Abstract:
The phenomenon of antimicrobial resistance (AMR) is a critical global health challenge,
with prospects indicating its potential to become the leading cause of death worldwide in the
coming years. Individuals with pre-existing conditions, such as neoplastic disease undergoing
chemotherapy, those on immunosuppressive therapy, and individuals with rare diseases like cystic
fibrosis (CF), face heightened challenges due to AMR. CF is a rare disease caused by a deficiency
in the synthesis of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channel
protein, resulting in multi-organ clinical symptoms, particularly in the respiratory system. PwCF
experience recurrent pulmonary exacerbations triggered by bacterial or viral infections, making
them particularly vulnerable to the impact of AMR. This review delves into the complex relationship
between AMR and climate dynamics, focusing on the unique challenges faced by individuals with CF.
It discusses the methods employed to measure AMR, its global impact on antibiotic resistance, and
the specific microbial communities present in the CF airway. The review also explores the intricacies
of antimicrobial resistance within the context of cystic fibrosis, emphasizing the urgent need for
research in this field.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
antimicrobial resistance (AMR); cystic fibrosis; pulmonary exacerbations; CFTR channel; microbial communities
Elenco autori:
A. Vitiello, F. Blasi, M. Sabbatucci, A. Zovi, F. Miele, A. Ponzo, R. Langella, M. Boccellino
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