Influence of adhesion-promoting glycolipids on the structure and stability of solid-supported lipid double-bilayers
Articolo
Data di Pubblicazione:
2024
Citazione:
Influence of adhesion-promoting glycolipids on the structure and stability of solid-supported lipid double-bilayers / L. Bange, T. Mukhina, G. Fragneto, V. Rondelli, E. Schneck. - In: SOFT MATTER. - ISSN 1744-6848. - 20:9(2024), pp. 2113-2125. [10.1039/D3SM01615C]
Abstract:
Glycolipids have a considerable influence on the interaction between adjacent biomembranes and can promote membrane adhesion trough favorable sugar-sugar "bonds" even at low glycolipid fractions. Here, in order to obtain structural insights into this phenomenon, we utilize neutron reflectometry in combination with a floating lipid bilayer architecture that brings two glycolipid-loaded lipid bilayers to close proximity. We find that selected glycolipids with di-, or oligosaccharide headgroups affect the inter-bilayer water layer thickness and appear to contribute to the stability of the double-bilayer architecture by promoting adhesion of adjacent bilayers even against induced electrostatic repulsion. However, we do not observe any redistribution of glycolipids that would maximize the density of sugar-sugar contacts. Our results point towards possible strategies for the investigation of interactions between cell surfaces involving specific protein-protein, lipid-lipid, or protein-lipid binding.Glycolipids affect the inter-bilayer water layer thickness and contribute to the stability of the double bilayer architecture through the formation of "sugar bonds".
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
L. Bange, T. Mukhina, G. Fragneto, V. Rondelli, E. Schneck
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