Organocatalytic Asymmetric Reduction of δ-Nitro Dienes: a Viable Entry to Functionalized Amines and Highly Substituted Enantioenriched Cyclopentanes
Articolo
Data di Pubblicazione:
2023
Citazione:
Organocatalytic Asymmetric Reduction of δ-Nitro Dienes: a Viable Entry to Functionalized Amines and Highly Substituted Enantioenriched Cyclopentanes / C. Faverio, F. Franco, G. Taini, L. Raimondi, M. Benaglia. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - (2023), pp. 1-6. [Epub ahead of print] [10.1002/ejoc.202301043]
Abstract:
δ-nitro dienes were successfully synthesized and converted to δ-nitro alkenes with complete chemo and regioselectivity. The enantioselective organocatalytic reduction was also accomplished and afforded the product in up to 97 % e.e. The chiral nitro alkene was further elaborated and employed as starting material in a stereoselective cyclization reaction that led to an almost enantiomerically pure highly functionalised cyclopentane featuring 5 contiguous stereocenters.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
chemoselectivity; dienes; enantioselective reduction; nitro alkenes; organocatalysis
Elenco autori:
C. Faverio, F. Franco, G. Taini, L. Raimondi, M. Benaglia
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