Data di Pubblicazione:
2023
Citazione:
Multiple genetic control of anti-COVID-19 vaccine response by HLA locus / F. Colombo, M. Esposito, F. Minnai, M. Copetti, G. Miscio, R. Perna, A. Piepoli, G. De Vincentis, M. Benvenuto, P. D'Addetta, S. Croci, M. Baldassarri, M. Bruttini, C. Fallerini, R. Brugnoni, F. Baggi, E. Corsini, E. Ciusani, F. Andreetta, T. Dragani, M. Fratelli, M. Carella, R. Mantegazza, A. Renieri. - (2023). [10.21203/rs.3.rs-3121965/v1]
Abstract:
Since the beginning of the anti-COVID-19 vaccination campaign, it has become evident that vaccinated subjects exhibit considerable inter-individual variability in the response to the vaccine that could be partly explained by host genetic factors. A recent study reported that the immune response elicited by the Oxford-AstraZeneca vaccine in individuals from the United Kingdom was influenced by a specific allele of the human leukocyte antigen gene HLA-DQB1. We performed a genome-wide association study to investigate the genetic determinants of the antibody response to the Pfizer-BioNTech vaccine in an Italian cohort of 1,351 subjects. We confirmed the involvement of the HLA locus and observed significant associations with variants in HLA-A gene. In particular, the HLA-A*03:01 was the most significantly associated with serum levels of anti-SARS-CoV-2 antibodies. These results support the hypothesis that HLA genes modulate the response to anti-COVID-19 vaccines and highlight the need for genetic studies in diverse populations.
Tipologia IRIS:
24 - Pre-print
Elenco autori:
F. Colombo, M. Esposito, F. Minnai, M. Copetti, G. Miscio, R. Perna, A. Piepoli, G. De Vincentis, M. Benvenuto, P. D'Addetta, S. Croci, M. Baldassarri, M. Bruttini, C. Fallerini, R. Brugnoni, F. Baggi, E. Corsini, E. Ciusani, F. Andreetta, T. Dragani, M. Fratelli, M. Carella, R. Mantegazza, A. Renieri
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