Gli inibitori della fosfodiesterasi-5 nella patologia cardiopolmonare: dai rilievi sperimentali all'applicazione clinica
Articolo
Data di Pubblicazione:
2009
Citazione:
Gli inibitori della fosfodiesterasi-5 nella patologia cardiopolmonare: dai rilievi sperimentali all'applicazione clinica / M. Guazzi, M. Vicenzi, M. Samaja. - In: GIORNALE ITALIANO DI CARDIOLOGIA. - ISSN 1827-6806. - 10:11-12(2009 Nov), pp. 725-737.
Abstract:
Phosphodiesterases are a class of proteins that primarily modulate intracellular levels of cyclic nucleotides such as cGMP and cAMP. Phosphodiesterase-5 (PDE5) is mainly involved in the smooth muscle cell cGMP inactivation. Chemical inhibition of PDE5 has recently become a valid therapeutic option of nitric oxide pathway potentiation via cell cGMP availability. More specifically, PDE5 inhibition appears successful for the treatment of idiopathic pulmonary arterial hypertension. Additional intriguing therapeutic properties are a protective effect on the myocardium through antihypertrophic and antiapoptotic mechanisms and on vascular function by improving endothelial responsiveness and tolerance to myocardial ischemia-reperfusion injury. These effects imply a potential usefulness in the treatment of coronary artery disease and heart failure. Evidence currently available for considering PDE5 inhibition an additional therapeutic opportunity in cardiovascular disorders is provided.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Heart failure; Pulmonary arterial hypertension
Elenco autori:
M. Guazzi, M. Vicenzi, M. Samaja
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