Clinimetrics of the cognitive section of the Italian ALS Cognitive Behavioral Screen (ALS-CBS™)
Articolo
Data di Pubblicazione:
2023
Citazione:
Clinimetrics of the cognitive section of the Italian ALS Cognitive Behavioral Screen (ALS-CBS™) / E.N. Aiello, L.C. Greco, A. La Tona, F. Solca, S. Torre, L. Carelli, D. Pain, A. Radici, A. Lizio, J. Casiraghi, F. Cerri, A. Brugnera, A. Compare, S. Woolley, J. Murphy, L. Tremolizzo, I. Appollonio, F. Verde, V. Silani, N. Ticozzi, C. Lunetta, V.A. Sansone, B. Poletti. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 44:4(2023 Apr), pp. 1243-1249. [10.1007/s10072-022-06569-9]
Abstract:
Background The present study aimed at (1) providing further validity and reliability evidence for the Italian version of the cognitive section of the ALS Cognitive Behavioral Screen (ALS-CBS (TM)) and (2) testing its diagnostics within an Italian ALS cohort, as well as at (3) exploring its capability to discriminate patients from healthy controls (HCs). Methods N = 293 non-demented ALS patients were administered the cognitive sections of the ALS-CBS (TM) and Edinburgh Cognitive and Behavioural ALS Screen (ECAS). N = 96 HCs demographically matched with N = 96 patients were also administered the cognitive section of the ALS-CBS (TM). In patients, factorial and construct validity, internal reliability, and diagnostics against a defective score on the cognitive section of the ECAS were tested. Case-control discrimination was assessed via a logistic regression. Results ALS-CBS (TM) cognitive subscales were underpinned by a simple, unidimensional structure, internally reliable (McDonald's omega = 0.74), and mostly related with ECAS executive and fluency scores (r(s) = 0.54-0.71). Both raw and age- and education-adjusted scores on the cognitive section of the ALS-CBS (TM) accurately detected ECAS-defined cognitive impairment (AUC = 0.80 and .88, respectively), yielding optimal error-based, information-based and unitary diagnostics. A cut-off of < 15.374 was identified on adjusted scores. The test was able to discriminate patients from HCs (p < 0.001). Discussion The cognitive section of the Italian ALS-CBS (TM) is a valid, reliable, and diagnostically sound ALS-specific screener for detecting frontotemporal, executive-/attentive-based cognitive inefficiency in non-demented ALS patients, being also able to discriminate them from normotypical individuals.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
ALS Cognitive Behavioral Screen; Amyotrophic lateral sclerosis; Clinimetrics; Cognitive screening; Frontotemporal degeneration; Neuropsychology
Elenco autori:
E.N. Aiello, L.C. Greco, A. La Tona, F. Solca, S. Torre, L. Carelli, D. Pain, A. Radici, A. Lizio, J. Casiraghi, F. Cerri, A. Brugnera, A. Compare, S. Woolley, J. Murphy, L. Tremolizzo, I. Appollonio, F. Verde, V. Silani, N. Ticozzi, C. Lunetta, V.A. Sansone, B. Poletti
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