Data di Pubblicazione:
2024
Citazione:
Central Precocious Puberty in Italian Boys: Data From a Large Nationwide Cohort / A. Cassio, G. Marescotti, T. Aversa, M. Salerno, G. Tornese, M. Stancampiano, G. Tuli, M.F. Faienza, P. Cavarzere, D. Fava, M. Parpagnoli, P. Bruzzi, A. Ibba, V. Calcaterra, C. Mameli, A. Grandone, V. Cherubini, V. Assirelli, F. Franchina, D. Capalbo, R.D. Mase, G. Tamaro, J. Cavasin, J. Munarin, G. Russo, M. Wasniewska. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - (2024), pp. dgae035.1-dgae035.10. [10.1210/clinem/dgae035]
Abstract:
Context: There are only a few nationwide studies on boys with central precocious puberty (CPP) and the last Italian study is a case series of 45 boys that dates back to 2000. Objective: We aimed to evaluate the causes of CPP in boys diagnosed during the last 2 decades in Italy and the relative frequency of forms with associated central nervous system (CNS) abnormalities on magnetic resonance imaging (MRI) compared to idiopathic ones. Methods: We performed a national multicenter retrospective study collecting data from 193 otherwise normal healthy boys with a diagnosis of CPP. Based on MRI findings, the patients were divided into: Group 1, no CNS abnormalities; Group 2, mild abnormalities (incidental findings) unrelated to CPP; and Group 3, causal pathological CNS abnormalities. Results: The MRI findings show normal findings in 86%, mild abnormalities (incidental findings) in 8.3%, and causal pathological CNS abnormalities in 5.7% of the cases. In Group 3, we found a higher proportion of patients with chronological age at diagnosis < 7 years (P = .00001) and body mass index greater than +2 SDS (P < .01). Gonadotropin-releasing hormone analogue therapy was started in 183/193 subjects. The final height appeared in the range of the target height in all groups and in 9 patients in whom the therapy was not started. Conclusion: In our study on a large nationwide cohort of boys referred for precocious puberty signs, the percentage of forms associated with CNS abnormalities was one of the lowest reported in the literature.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
boys; central precocious puberty; magnetic resonance imaging
Elenco autori:
A. Cassio, G. Marescotti, T. Aversa, M. Salerno, G. Tornese, M. Stancampiano, G. Tuli, M.F. Faienza, P. Cavarzere, D. Fava, M. Parpagnoli, P. Bruzzi, A. Ibba, V. Calcaterra, C. Mameli, A. Grandone, V. Cherubini, V. Assirelli, F. Franchina, D. Capalbo, R.D. Mase, G. Tamaro, J. Cavasin, J. Munarin, G. Russo, M. Wasniewska
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