Lack of efficacy of a starch-thickened preterm formula on gastro-oesophageal reflux in preterm infants: A pilot study
Articolo
Data di Pubblicazione:
2012
Citazione:
Lack of efficacy of a starch-thickened preterm formula on gastro-oesophageal reflux in preterm infants: A pilot study / L. Corvaglia, A. Aceti, E. Mariani, E. Legnani, M. Ferlini, G. Raffaeli, G. Faldella. - In: THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. - ISSN 1476-4954. - 25:12(2012), pp. 2735-2738. [10.3109/14767058.2012.704440]
Abstract:
Background: Gastro-oesophageal reflux (GOR) is common in preterm infants; conservative interventions (i.e. dietary changes) should represent the first-line approach. Aim: To evaluate by combined pH and impedance monitoring (pH-MII) the effect of a new preterm formula thickened with amylopectin (TPF) on GOR features in symptomatic preterm infants. Methods: Twenty-eight symptomatic preterm newborns underwent a 24-hour pH-MII; each baby received eight meals (four of TPF and four of a preterm formula [PF]). GOR indexes (number, acidity, duration and height of GORs) after TPF and PF meals were compared by Wilcoxon Signed Ranks Test. Viscosity of PF and TPF was measured. Results: TPF significantly decreased the number of acid GORs detected by pH-monitoring (TPF vs. PF: median 20 vs. 24.5, p = 0.009), while it had no influence on Reflux Index (RIpH), nor on acid and non-acid GOR indexes detected by MII, GOR physical features, and GOR height. TPF's viscosity was extremely higher than PF's, and further increased at pH 3 after the addition of pepsin. Conclusions: The new formula was found to reduce the number of acid GORs detected by pH-monitoring; it did not reduce neither total oesophageal acid exposure nor non-acid GORs. At present its extended clinical use cannot be recommended.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
gastro-oesophageal reflux; pH and impedance monitoring; preterm infant; thickened formula
Elenco autori:
L. Corvaglia, A. Aceti, E. Mariani, E. Legnani, M. Ferlini, G. Raffaeli, G. Faldella
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