Data di Pubblicazione:
2016
Citazione:
Alternative approach for potency assessment: In vitro methods / E. Corsini, E.L. Roggen, V. Galbiati, S. Gibbs. - In: COSMETICS. - ISSN 2079-9284. - 3:1(2016), pp. 7.1-7.9. [10.3390/cosmetics3010007]
Abstract:
Over the last decade, incredible progress has been made in the development of non-animal tests to assess contact hypersensitivity. Fourmethods have been successfully validated andOrganisation for Economic Co-operation and Development (OECD) guidelines are available or soon will be. Currently validated methods are useful for hazard identification, classification and labeling. However, to achieve a complete replacement of animals in skin sensitization assessment, dose-response information and evaluation of relative skin sensitizing potency to support effective risk assessment are necessary. In this context, potency is based on the concentration of chemicals needed to induce a positive response. This will require a better understanding of the mechanisms determining potency, including pathway analysis and marker signature identification (selection of an appropriate immune-mediated response to serve as the basis), together with quantitative and qualitative correlations between marker signatures and potency of chemicals in relation with T cell responses. This review aims to discuss the state-of-the-art in the field of in vitro assessment of the no induction sensitization level of contact sensitizers.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Allergy; Dendritic cells; In vitro immunotoxicology; Keratinocytes; Potency
Elenco autori:
E. Corsini, E.L. Roggen, V. Galbiati, S. Gibbs
Link alla scheda completa: