Data di Pubblicazione:
2006
Citazione:
Formation of self-organized nanoparticels by lecithin/chitosan ionic interaction / F. Sonvico, A. Cagnani, A. Rossi, S. Motta, M.T. Di Bari, F. Cavatorta, M.J. Alonso, A. Deriu, P. Colombo. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - 324:1(2006), pp. 67-73.
Abstract:
In this work the production of auto-assembled nanoparticles obtained by the mixing of chitosan and lecithin is presented. The size and surface
charge of the nanoparticles were studied as function of the weight ratio between components, the viscosity of the polysaccharide and the pH of the
colloidal suspension.
In order to elucidate the structure of nanoparticles, micro-FT-IR and elastic neutron scattering experiments have been performed. Results
evidenced a strong electrostatic interaction between components and a structure that is neither that of homogeneous spheres nor of coated
unilamellar vesicles. Preliminary encapsulation experiments with progesterone, as model lipophilic drug, showed good encapsulation efficiencies.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Chitosan; Lecithin; Nanoparticles; Self-organizing structures
Elenco autori:
F. Sonvico, A. Cagnani, A. Rossi, S. Motta, M.T. Di Bari, F. Cavatorta, M.J. Alonso, A. Deriu, P. Colombo
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