La determinazione della troponina T con il metodo ad alta sensibilità migliora la sensibilità di rilevazione della cardiomiopatia nell'amiloidosi AL
Articolo
Data di Pubblicazione:
2010
Citazione:
La determinazione della troponina T con il metodo ad alta sensibilità migliora la sensibilità di rilevazione della cardiomiopatia nell'amiloidosi AL / G. Sarais, A. Barassi, G. Palladini, R. Capra, A. Foli, P. Russo, R. Albertini, L. Zenone Bragotti, L. Obici, R. Moretti, G. Melzi d'Eril, G. Merlini. - In: BIOCHIMICA CLINICA. - ISSN 0393-0564. - 34:3(2010), pp. 199-202.
Abstract:
In AL amyloidosis cardiac involvement dictates prognosis. It has been demonstrated that cardiac dysfunction is best assessed by measuring serum concentrations of N-terminal B-type natriuretic peptide (NT-proBNP) and cardiac troponins. Recently, a new generation of more sensitive assays for troponin measurement has been developed, aiming at identifying minimal cardiac damage. We report the impact of the introduction of a highly sensitive cardiac troponin T (hs-cTnT) assay (Roche Diagnostics) on the detection of cardiac involvement in 109 consecutive newly diagnosed patients with AL amyloidosis. The hs-cTnT was determined on the Modular E system. Cardiac troponin I (cTnI) (Siemens TnI-Ultra™) and NT-proBNP (Roche Diagnostics) were also measured. Sixty nine (63%) patients had cardiac involvement at presentation, as detected by echocardiography. The diagnostic sensitivity of the biomarkers to detect cardiac involvement at diagnosis was 74% for cTnI, 96% for hs-cTnT, and 100% for NT-proBNP, respectively. In additional 15 patients, echographic evidence of amyloid heart involvement developed during 6 months following diagnosis: cTnI was elevated at presentation in 5 cases (33%), hs-cTnT in 12 (80%, P=0,01 versus cTnI) and NT-proBNP in 11 cases (73%). We conclude that hs-cTnT may improve the sensitivity for detection of cardiac damage caused by AL amyloidosis.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
G. Sarais, A. Barassi, G. Palladini, R. Capra, A. Foli, P. Russo, R. Albertini, L. Zenone Bragotti, L. Obici, R. Moretti, G. Melzi d'Eril, G. Merlini
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