Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine
Articolo
Data di Pubblicazione:
1999
Citazione:
Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine : a new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine / P. Ciuffreda, S. Casati, E. Santaniello. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 9:11(1999 Jun 07), pp. 1577-1582.
Abstract:
The selective acylation of the hydroxy groups of the nucleosides inosine la and 2'-deoxyinosine Ib has been achieved in the presence of Candida antarctica and Pseudomonas sp. lipases in organic solvents ; starting from the 5'-acetyl derivative of 2'-deoxyinosine, an efficient chemoenzymatic synthesis of the antiviral drug 2',3'-dideoxyinosine has been achieved
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
P. Ciuffreda, S. Casati, E. Santaniello
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