Two Years of Active Pharmacovigilance Surveillance and Therapeutic Reconciliation in Frail Populations: The MEAP 3.0 Study
Articolo
Data di Pubblicazione:
2023
Citazione:
Two Years of Active Pharmacovigilance Surveillance and Therapeutic Reconciliation in Frail Populations: The MEAP 3.0 Study / A. Bombelli, G. Guarnieri, N. Lombardi, M.G. Sullo, E. Spina, G. Crescioli, C. Rafaniello, G. Cicala, V. Marangon, R. Folchino, S. Vecchio, G. Mosini, S. Radice, E. Clementi. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 12:23(2023), pp. 7447.1-7447.13. [10.3390/jcm12237447]
Abstract:
Awareness related to the risk/benefit profile of therapies used in paediatric and elderly
patients is limited. We carried out a study, called the MEAP 3.0 study, to collect and analyse
evidence of adverse drug reactions (ADRs) and drug–drug interactions (DDIs) that occurred in frail
populations under polypharmacy in a real-world setting. Data were retrieved from reports of ADRs
and pharmacological counselling from patients treated in hospitals and territorial health services.
We collected 2977 ADRs reports and identified ‘anti-infectives for systemic use’ and ‘cardiovascular
system’ as the most frequently implicated pharmacological classes in under-18 and over-65 patients,
respectively. We detected 2179 DDIs, of which 10.7% were related to at least one ADR: 22 were
classified as ‘contraindicated’ (7 in the paediatric group and 15 in the elderly one), and 61 as ‘major’
(6 in the paediatric patients and 55 in the geriatric ones), while 151 DDIs were classified as ‘moderate’
(10 referred to paediatric population, and 109 to elderly patient) and as ‘minor’ (1 in paediatric
patients, and 31 in the elderly ones). The MEAP 3.0 project demonstrates that pharmacovigilance
surveillance and therapeutic reconciliation are valid strategies to avoid potential DDIs and the
occurrence of ADRs, allowing for personalised medicine.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
adverse drug reaction; drug–drug interaction; paediatric; elderly; frail populations; pharmacovigilance; polypharmacy; therapeutic reconciliation; personalised medicine
Elenco autori:
A. Bombelli, G. Guarnieri, N. Lombardi, M.G. Sullo, E. Spina, G. Crescioli, C. Rafaniello, G. Cicala, V. Marangon, R. Folchino, S. Vecchio, G. Mosini, S. Radice, E. Clementi
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