Cystic fibrosis systemic immune profile is associated with lung microbes and characterized by widespread alterations in the innate and adaptive immune compartments
Articolo
Data di Pubblicazione:
2023
Citazione:
Cystic fibrosis systemic immune profile is associated with lung microbes and characterized by widespread alterations in the innate and adaptive immune compartments / E. Rossi, M. Lausen, N. Friesgård Øbro, A. Colque, B. Uhre Nielsen, R. Møller, C. de Gier, A. Hald, M. Skov, T. Pressler, S. Molin, S. Rye Ostrowski, H. Vibeke Marquart, H. Krogh Johansen. - (2023 Aug 23). [10.1101/2023.08.23.553085]
Abstract:
Polymicrobial airway infections and detrimental inflammation characterize patients with cystic fibrosis (CF), a disease with heterogeneous clinical outcomes. How the overall immune response is affected in CF, its relationships with the lung microbiome, and the source of clinical heterogeneity are unclear. Our work identifies a specific CF immune profile characterized by widespread hyperactivation, enrichment of CD35+/CD49d+ neutrophils, and reduction in dendritic cells. Further, our data indicate signs of immune dysregulation due to alterations in Tregs homeostasis, which, together with an impaired B-cell immune function, are linked with patients’ lung function and are potentially the source of clinical heterogeneity. Indeed, clinical heterogeneity does not stem from a specific lung microbiome; yet, commensal bacteria correlate with higher concentrations of circulating immune cells and lower expression of leukocyte activation markers, a condition reversed by pathogenic microorganisms. Overall, our findings provide unique markers and immunomodulatory targets for improving the treatment of CF.
Tipologia IRIS:
24 - Pre-print
Elenco autori:
E. Rossi, M. Lausen, N. Friesgård Øbro, A. Colque, B. Uhre Nielsen, R. Møller, C. de Gier, A. Hald, M. Skov, T. Pressler, S. Molin, S. Rye Ostrowski, H. Vibeke Marquart, H. Krogh Johansen
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