Data di Pubblicazione:
2023
Citazione:
Addressing Motor Dysfunction by a Selective α6-Containing Nicotinic Receptor Antagonist / C. Bolchi, M. Pallavicini. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 1520-4804. - 66:21(2023 Nov), pp. 14494-14496. [10.1021/acs.jmedchem.3c01817]
Abstract:
In the striatum, presynaptic α6-containing nicotinic receptors are crucially involved in the modulation of dopamine release. CVN417, a novel selective antagonist at this receptor subtype, attenuates motor dysfunction in a Parkinson’s disease-relevant animal model, suggesting, for this pathology, a therapeutic strategy that could greatly profit from the restricted localization of α6* nicotinic receptors in the brain.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
C. Bolchi, M. Pallavicini
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