Data di Pubblicazione:
2022
Citazione:
A perspective on diet, epigenetics and complex diseases: where is the field headed next? / F. Coppedè, M. Franzago, E. Giardina, C. Lo Nigro, G. Matullo, C. Moltrasio, B. Nacmias, S. Pileggi, S.M. Sirchia, A. Stoccoro, C. Tiziana Storlazzi, L. Stuppia, R. Tricarico, G. Merla. - In: EPIGENOMICS. - ISSN 1750-1911. - 14:20(2022 Oct), pp. 1281-1304. [10.2217/epi-2022-0239]
Abstract:
Dietary factors can regulate epigenetic processes during life, modulating the intracellular pools of metabolites necessary for epigenetic reactions and regulating the activity of epigenetic enzymes. Their effects are strong during the prenatal life, when epigenetic patterns are written, allowing organogenesis. However, interactions between diet and the epigenome continue throughout life and likely contribute to the onset and progression of various complex diseases. Here, we review the contribution of dietary factors to the epigenetic changes observed in complex diseases and suggest future steps to better address this issue, focusing on neurobehavioral, neuropsychiatric and neurodegenerative disorders, cardiovascular diseases, obesity and Type 2 diabetes, cancer and inflammatory skin diseases.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
cancer; cardiovascular diseases; diet; epigenetics; inflammatory skin diseases; neurobehavioral disorders; neurodegenerative diseases; obesity and Type 2 diabetes
Elenco autori:
F. Coppedè, M. Franzago, E. Giardina, C. Lo Nigro, G. Matullo, C. Moltrasio, B. Nacmias, S. Pileggi, S.M. Sirchia, A. Stoccoro, C. Tiziana Storlazzi, L. Stuppia, R. Tricarico, G. Merla
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